Gut Disruption May Increase Risk of Breast Cancer Metastasis

Microbiome disruption can cause breast cancer to spread more quickly to other parts of the body, according to a new study published in Cancer Research.
 
A healthy microbiome is known to be vital for many aspects of good health. In this study, the researchers examined the effect of disrupting gut bacteria on hormone receptor-positive breast cancer, which can be more aggressive and invasive in some patients.
 
According to the study, mice whose microbiomes were disrupted through chronic antibiotic treatment experienced an increase in inflammation systemically and within the mammary tissue, which primed the cancer to spread.
 
“In this inflamed environment, tumor cells were much more able to disseminate from the tissue into the blood and to the lungs, which is a major site for hormone receptor-positive breast cancer to metastasize,” Melanie Rutkowski, PhD, of the University of Virginia Cancer Center’s Department of Microbiology, Immunology, and Cancer Biology, said in a press release about the study.
 
Rutkowski explained that early metastasis in breast cancer is affected by several factors, including a high level of immune cells called macrophages within the tissue and increased amounts of the structural protein collagen in the tissue and tumor. In the study, microbiome disruption increased the production of both macrophages and collagen in a sustained effect. Thus, the findings suggest that gut disruption and the subsequent changes that occur as a result may be early predictors of invasive or metastatic breast cancer, according to Rutkowski.
 
“Ultimately, based upon these findings, we would speculate that an unhealthy microbiome contributes to increased invasion and a higher incidence of metastatic disease,” she said.
 
Although the researchers used antibiotics, they noted that this was only meant to create a long-term imbalance in the microbiome and does not determine an association between chronic antibiotic usage and cancer outcomes. Additionally, the mice were treated with powerful antibiotics in a more exaggerated model than a person taking a normal course of antibiotics.
 
To promote a healthy microbiome, Rutkowski suggested “a healthy diet, high in fiber, along with exercise, sleep—all of those things that contribute to positive overall health.”
 
Taking steps to improve gut health can potentially lead more favorable long-term for breast cancer.
 
References
 
Rutkowski MR, Rosean CB, Bostic RR, et al. Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer. Cancer Research. 2019. Doi: 10.1158/0008-5472.CAN-18-3464
 
Unhealthy Gut Promotes Spreads of Breast Cancer, Study Finds [news release]. University of Virginia Health System. https://newsroom.uvahealth.com/2019/06/10/unhealthy-gut-promotes-spread-of-breast-cancer-study-finds/. Accessed June 10, 2019.
 
 



Stay up to date on the latest news in specialty pharmacy by getting Specialty Pharmacy Times in your mailbox or inbox for free!

Click here to sign up for free for the bi-monthly Specialty Pharmacy Times print journal delivered to your address.

Click here to sign up for our email newsletters delivered every Monday, Wednesday, and Friday, in addition to breaking news alerts.

Click here to follow us on Facebook. 

Click here to follow us on Twitter. 

Click here to join our LinkedIn group. 


Related Articles

The presence of human papillomavirus type 16 antibodies marked an approximately 100-fold increase in risk of throat cancer in white individuals.
Colon cancer may spread to other parts of the body before original tumors are clinically detectable.
Top news of the day from across the health care landscape.
Company Profile >
Industry Guide >
Market News >
Peer Exchange >
Conferences >
Subscribe >
Specialty Times Resources
About Us
Advertise
Careers
Contact Us
Terms & Conditions
Privacy
MJH Associates >
Pharmacy Times
OTCGuide
American Journal of Managed Care
Cure
MD Magazine
ONCLive
Targeted Oncology
Physicians' Education Resource
Pharmacy & Healthcare Communications, LLC
2 Clarke Drive
Suite 100
Cranbury, NJ 08512
P: 609-716-7777
F: 609-716-4747

Copyright Specialty Pharmacy Times 2006-2019
Pharmacy & Healthcare Communications, LLC. All Rights Reserved.
 

$vacMongoViewPlus$