Antioxidant Supplementation Associated with Reduced Respiratory Illnesses in Patients with Cystic Fibrosis

Treatment with antioxidant-enriched multivitamins may reduce respiratory illnesses in individuals with cystic fibrosis (CF), according to a new study published in the American Journal of Respiratory and Critical Care Medicine.1
 
In the study, the researchers examined how a cocktail of multiple antioxidants affected inflammation and health outcomes in patients with CF over a 16-week period. The study included 73 pancreatic-insufficient patients with CF aged 10 years and older.
 
Patients in the study do not ordinarily absorb dietary antioxidants, including carotenoids such as beta-carotene, vitamin E, CoQ10, and selenium, which can help neutralize inflammation in the body. The capsules used in the study were specifically designed for individuals with difficulties absorbing important dietary antioxidants, including carotenoids such as beta-carotene, vitamin E, coenzyme, and selenium.
 
The patients were divided in 2 groups: 1 group of patients received the supplemental antioxidants and the second group received a control multivitamin without added antioxidants. Endpoints included systemic antioxidant concentrations, markers of inflammation and oxidative stress, clinical outcomes, safety, and tolerability.
 
According to the researchers, supplementation increased antioxidant concentrations in the blood of the participants and temporarily reduced inflammation in the blood at 4 weeks, but not at 16 weeks.
 
Additionally, half as many of the patients taking supplemental antioxidants experienced a pulmonary exacerbation requiring antibiotics compared with the group taking the control multivitamin. Patients in the group treated with antioxidants also experienced a lower frequency of respiratory illnesses compared with the control group.
 
Adverse events and tolerability were similar between groups.
 
“While more research certainly needs to be done to find a treatment that delivers a sustained anti-inflammatory effect, we believe the fact that this antioxidant supplement prolonged the time patients had before their first illness is meaningful,” Scott D Sagel, MD, PhD, pediatric pulmonologist at Children’s Hospital Colorado and professor of pediatrics at the University of Colorado School of Medicine, said in a press release.2 “It offers a simple, relatively inexpensive means for restoring and maintaining normal antioxidant levels in people who would otherwise have trouble doing so.”
 
Reference
 
1.     Sagel SD, Khan U, Jain R, et al. Effects of an antioxidant-enriched multivitamin in cystic fibrosis: randomized, controlled, multicenter trial. American Journal of Respiratory and Critical Care Medicine. 2018. https://doi.org/10.1164/rccm.201801-0105OC  
 
2.     Study finds antioxidant-enriched multivitamin reduces respiratory multivitamin reduces respiratory illnesses in patients with cystic fibrosis [news release]. Children’s Hospital Colorado website. https://www.childrenscolorado.org/about/news/2018/may-2018/cystic-fibrosis-vitamin-study/. Accessed May 29, 2018. 


Stay up to date on the latest news in specialty pharmacy by getting Specialty Pharmacy Times in your mailbox or inbox for free!

Click here to sign up for free for the bi-monthly Specialty Pharmacy Times print journal delivered to your address.

Click here to sign up for our email newsletters delivered every Monday, Wednesday, and Friday, in addition to breaking news alerts.

Click here to follow us on Facebook. 

Click here to follow us on Twitter. 

Click here to join our LinkedIn group. 


Most Popular

Related Articles

Patients with cystic fibrosis (CF) who were treated with ivacaftor have demonstrated favorable results for clinically important outcomes, according to a new study.
Rates of hospital inpatient admissions before and during use of ivacaftor found that overall and cystic fibrosis-related inpatient admissions fell by 55% and 81%, respectively.
Officials with the FDA granted orphan drug designation for Reviva Pharmaceuticals’ clinical stage drug candidate, RP5063 for treatment of idiopathic pulmonary fibrosis.
Company Profile >
Contributors >
Industry Guide >
Market News >
Peer Exchange >
Conferences >
Subscribe >
Specialty Times Resources
About Us
Advertise
Careers
Contact Us
Terms & Conditions
Privacy
MJH Associates >
Pharmacy Times
OTCGuide
American Journal of Managed Care
Cure
MD Magazine
ONCLive
Targeted Oncology
Physicians' Education Resource
Pharmacy & Healthcare Communications, LLC
2 Clarke Drive
Suite 100
Cranbury, NJ 08512
P: 609-716-7777
F: 609-716-4747

Copyright Specialty Pharmacy Times 2006-2018
Pharmacy & Healthcare Communications, LLC. All Rights Reserved.
 

$vacMongoViewPlus$